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Conclusions: We document that S6-p S240 is expressed in lesional areas of skin biopsies from patients with autoimmune skin blistering diseases, as well as on eccrine glands and piloerector muscles.
Thus, the role of this molecule in autoimmune skin blistering diseases warrants further study.
(c) A BP case, displaying positivity in a subepidermal blister area (brown staining; red arrow) and in a dermal mesenchymal/endothelial cell junction-like structure (brown staining; black arrow).
(d and e) Two different cases of El Bagre-endemic pemphigus foliaceus (EPF), demonstrating reactivity in dermal piloerector muscles (brown staining; red arrows).
Correspondence Address: Ana Maria Abreu Velez Georgia Dermatopathology Associates, 1534 North Decatur Rd., NE; Suite 206; Atlanta, Georgia 30307-1000 Georgia Source of Support: Georgia Dermatopathology Associates, Atlanta, Georgia, USA (MSH, AMAV); Mineros SA, Medellin, Colombia, SA; Embassy of Japan in Colombia, Medellin; University of Antioquia, Medellin; Knoxville Dermatopathology Laboratory, Knoxville, Tennessee, USA (PBG)., Conflict of Interest: None Background: The in situ signaling transduction within skin biopsies from patients affected by autoimmune skin blistering diseases is not well-characterized.
Aim : In autoimmune skin blistering diseases, autoantibodies seem to trigger several intracellular signaling pathways and we investigated the presence of the phosphorylated form of ribosomal protein S6-p S240 within autoimmune skin blistering diseases biopsies.
We evaluated 20 biopsies from bullous pemphigoid (BP) patients, 20 from patients with pemphigus vulgaris (PV), eight patient biopsies with pemphigus foliaceus (PF), and 12 from patients with dermatitis herpetiformis (DH).
A large number of cellular events induced in target keratinocytes by ABD autoantibodies have been described, and suggest that ABD autoantibodies bind to their target antigens and trigger a complex cascade of intracellular signaling and regulatory events.
Several intracellular signaling pathways, such as p38MAPK activation and Rho A inhibition, pemphigus Ig G activation-translocation of protein kinase C, and imbalances in both Akt/m TOR and cyclic adenosine 5'- monophosphate signaling have been demonstrated to be altered following autoantibody binding and to be causally involved in loss of keratinocyte cohesion.
Specifically, we performed a pilot study to search for the presence of this phosphorylated enzyme in the in situ immune response of ABDs by performing immunohistochemistry (IHC) staining on lesional skin biopsies.
Subjects of study We tested 30 biopsies from patients affected by endemic pemphigus foliaceus (EPF) in El Bagre, Colombia, South America (El Bagre-EPF) and 15 skin biopsies from normal controls from the El Bagre-EPF endemic area (NCEA).